Mirataz™(mirtazapine transdermal ointment)

Mirataz is a transdermal formulation of mirtazapine under development to be used in cats for the management of weight loss. Mirataz is a novel product that utilizes KindredBio’s Accusorb™ technology and has been shown to result in measurable blood levels of mirtazapine.

Weight loss and anorexia occur commonly in cats due to various causes and are estimated to occur in millions of cats per year.1,2 Weight loss and anorexia can result in serious outcomes including hepatic lipidosis (fatty liver) leading to liver failure and even death.3 Managing weight loss in cats with acute or chronic illness may help to avoid clinically significant metabolic changes and may improve the cat’s longevity and quality of life.

There are no approved veterinary drugs to manage weight loss in cats despite millions of cats needing treatment per year. Currently practitioners must rely on off-label use of human oral mirtazapine or compounded mirtazapine, both of which have limitations.3-5

The application for Mirataz is currently under review at the FDA Center for Veterinary Medicine (CVM). Approval and launch of the drug is expected in 2017.

1 U.S. Veterinarian Mirtazapine Phase 2 Research, Wise Insights, May 2016 (n=89 U.S. small animal veterinarians).  U.S. Veterinarian Mirtazapine Phase Research, Ipsos, September 2016 (n=201 U.S. small animal veterinarians). Data on file at KindredBio.

2 Freeman LM, Lachaud MP, Rhodes L, and Zollers B.  Evaluation of weight loss over time in cats with chronic kidney disease.  J Vet Int Med. 2016; 30:1661-1666.

3 Agnew W and Kirman R.  Pharmacological appetite stimulation: rationale choices in the inappetent cat.  J Feline Med Surg. 2014 Sep; 16(9):749-56.

4 Quimby JM and Lunn KE.  Mirtazapine as an appetite stimulant and anti-emetic in cats with chronic kidney disease: a masked placebo-controlled crossover clinical trial. Vet J. 2013 Sep; 197(3):651-5.

5 Epub: Benson KK, Zajic LB, Morgan P, Brown S, Hansen RJ, Lunghofer PJ, Wittenburg LA Gustafson DL and Quimby JM. Drug exposure and clinical effect of transdermal mirtazapine in healthy young cats: a pilot study. J Fel Med Surg. 2016 Sep 9. pii: 1098612X16667168.